Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy.
نویسندگان
چکیده
منابع مشابه
Increased CD 80 1 B Cells in Active Multiple Sclerosis and Reversal by Interferon b - 1 b Therapy
Costimulatory molecules help determine T cell responses. CD80 (B7-1) and CD86 (B7-2), costimulatory proteins on antigen-presenting cells, bind to CD28 on T cells. When costimulation is coupled with a signal through the T cell receptor (TCR), T cell proliferation and cytokine secretion are induced. However, TCR signaling without CD80/CD86CD28 costimulation causes anergy. During multiple sclerosi...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119455